Dr. David Sinclair's Supplement Protocol

    From Longevity Wiki

    This article presents a comprehensive list of compounds taken by Dr. David Sinclair, a leading figure in aging and longevity research. The information was collected from official videos featuring Dr. Sinclair, where he discusses his personal regimen and the reasoning behind it.

    For anyone interested in the specifics of what Dr. Sinclair has said, each video mentioned in this article is accompanied by a link. These links direct you to the full transcripts of the interviews, allowing readers to easily search and verify his statements. This way, you can read exactly what Dr. Sinclair said about each substance, ensuring accuracy and understanding of his recommendations.

    It's important to remember that while Dr. Sinclair shares his personal choices, these are based on his own research and health status. Everyone is different, and what works for one person might not work for another. Always talk to a healthcare provider before starting any new health regimen.

    Enjoy discovering more about these substances and Dr. Sinclair's insights into longevity!


    Substance Dose When Comment
    Nicotinamide Mononucleotide (NMN) 1000 mg Morning As capsules with some water[1]. Mid of 2023 he mentioned that he takes NMN since 8 to 10 years.[2]
    Resveratrol 1000 mg Morning Started taking it in his early 30s[3]
    Metformin 800 mg Night, not when he making excercise the next day and muscles are growing
    Spermidine 1000 mg Morning
    Quercetin 500 mg Morning In [4] Dr. Sinclair mentoined that he took quercetin and fisetin around Jan 2022 for one month.
    Fisetin 500 mg Morning
    Vitamin D3 4,000 to 5,000 IUs
    Vitamin K2 180 to 360 mcg
    Vitamin Bs (B3, B6, B12) Variable Monitors Vitamin B levels with Inside Tracker because you want not too much and not too low
    Low-Dose Aspirin 83 mg Night
    Trimethylglycine (TMG) 500 - 1000 mg In a 2019 interview [5], Dr. Sinclair mentioned that he takes TMG as a precautionary measure, suggesting that excessive NMN supplementation might deplete the body's available methyl groups. However, only audio files of this interview remain, as the YouTube video was deleted. Notably, he hasn't mentioned TMG in any subsequent podcasts or videos, leading to the assumption that Dr. Sinclair might no longer be taking TMG.
    Alpha Lipoic Acid (ALA) Night
    Selenium By eating Brazil nuts
    Satin Takes Satin since he was 29 because his cholesterol was way up (beyond 300) and his grandmother had a stroke in her 30s.
    Coenzyme Q10 (coQ10) Night coQ10 is to make sure that the Satin doesn't deplete that too much
    Omega 3-6-9 (fish oil)
    Taurine 2000 mg
    Rapamycin On and off

    Mentioned in Videos

    X = Taking, M = Taking in the morning, N = Taking at night, T = Taking temporarily
    NMN Reseratrol Metformin Berberine Spermidine Quercetin Fisetin Vitamin D3 Vitamin K2 Vitamin Bs Low-Dose Aspirin TMG ALA Statin coQ10 Omega 3-6-9 Selenium Magnesium GABA L-Theanin Taurine Rapamycin
    Lifespan: Why We Age – and Why We Don’t Have To Sept. 2019 X X X X X X
    2021-12-27 - Interview Dr. David Sinclair - Huberman Lab Podcast - The Biology of Slowing & Reversing Aging Dec 2021 X X M
    2022-01-26 - Podcast Dr. David Sinclair - NMN, NR, Resveratrol, Metformin & Other Longevity Molecules Jan 2022 X X N X X X
    2022-08-30 - Interview Dr. David Sinclair - Optimize Longevity - What To Eat & When For Longevity Aug 2022 X X X X X X N N X N X X
    2022-08-31 - Interview Dr. David Sinclair - Optimize Longevity - Longevity Molecules and Supplements Aug 2022 M X X X T T
    2022-09-02 - Interview Dr. David Sinclair - Optimize Longevity - Keeping Your Brain Young Sep 2022 X X X N N N
    2023-04-13 - Talk Dr. David Sinclair - Majlis Lecture Series - Why We Age and Why We Don't Have To Apr 2023 M




    X M


    X X X X X
    2023-07-17 - Interview Dr. David Sinclair - Optimize Longevity - Build Muscle & Maintain Longevity Jul 2023 N X X
    2023-08-24 - Interview Dr. David Sinclair - Moonshots with Peter Diamandis - Aging is Now Optional (Abundance360) Aug 2023 X

    See Also