Lifespan: Why We Age – and Why We Don't Have To

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    Lifespan: Why We Age – and Why We Don't Have To is a book by David A. Sinclair published on September 10, 2019.


    Lifespan has three parts:

    • "Part I: What We Know (The Past)" – contains 3 chapters
    • "Part II: What We're Learning (The Present)" – contains 4 chapters
    • "Part III: Where We're Going (The Future)" – contains 2 chapters

    The book also contains an introduction and conclusion.

    The authors begin by seeking to characterize how professionals view the hallmarks of aging, including genomic instability caused by DNA damage; alterations to the epigenome that controls which genes are turned on and off; loss of healthy protein maintenance, known as proteostasis; exhaustion of stem cells; and the production of inflammatory molecules.

    "Address one of these, and you can slow down aging," the authors argue. "Address all of them, and you might not age."

    David Sinclair's Longevity Interventions

    On page 304 David Sinclairs mentioned what he was doing in 2019. See Dr. David Sinclair's Supplement Protocol what he is taking currently.

    • I take 1 gram (1,000 mg) of NMN every morning, along with 1 gram of resveratrol (shaken into my homemade yogurt) and 1 gram of metformin.
    • I take a daily dose of vitamin D, vitamin K2, and 83 mg of aspirin.
    • I strive to keep my sugar, bread, and pasta intake as low as possible. I gave up desserts at age 40, though I do steal tastes.
    • I try to skip one meal a day or at least make it really small. My busy schedule almost always means that I miss lunch most days of the week.
    • Every few months, a phlebotomist comes to my home to draw my blood, which I have analyzed for dozens of biomarkers. When my levels of various markers are not optimal, I moderate them with food or exercise.
    • I try to take a lot of steps each day and walk upstairs, and I go to the gym most weekends with my son, Ben; we lift weights, jog a bit, and hang out in the sauna before dunking in an ice-cold pool.
    • I eat a lot of plants and try to avoid eating other mammals, even though they do taste good. If I work out, I will eat meat.
    • I don't smoke. I try to avoid microwaved plastic, excessive UV exposure, X-rays, and CT scans.
    • I try to stay on the cool side during the day and when I sleep at night.
    • I aim to keep my body weight or BMI in the optimal range for healthspan, which for me is 23 to 25.

    See Also