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    Reported resveratrol plasma concentration in humans after repeated doses of resveratrol (studies after 2010). [1]
    Number of Participants, Characteristics, Study Type Dose
    Days Administration Peak Plasma Concentration
    6, low BMI 2125 11 Tablet and drink 903.0
    6, high BMI 245.0
    35, healthy males, cross-over study 800 5 Capsule 0.56
    Dairy drink 0.61
    Soy drink 0.58
    Protein-free drink 0.70
    7, healthy 500 28 Capsule with Piperine 2967.25
    40, healthy, repeated sequential dosing 500 29 Caplet 43.8
    1000 141
    2500 331
    5000 967
    6, patients with hepatic metastases, randomized double-blind clinical trial 5000 14 Micronized resveratrol mixed in liquid 1942
    8, healthy subjects 2000 7 Capsule 1274
    19, overweight or obese, randomized, double-blind, placebo-controlled, crossover intervention 30 6 Capsule 181.31
    90 532.00
    270 1232.16
    1. Springer M & Moco S: Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Nutrients 2019. (PMID 30641865) [PubMed] [DOI] [Full text] Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported molecular mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use.