Translations:Resveratrol/39/de
| Anzahl der Teilnehmer, Merkmale, Studientyp | Dosis (mg/Tag) |
Tage | Verabreichung | Spitzen-Plasmakonzentration (ng/mL) |
|---|---|---|---|---|
| 6, niedriger BMI | 2125 | 11 | Tablette und Getränk | 903,0 |
| 6, hoher BMI | 245,0 | |||
| 35, gesunde Männer, Cross-over-Studie | 800 | 5 | Kapsel | 0,56 |
| Milchgetränk | 0,61 | |||
| Sojagetränk | 0,58 | |||
| Proteinfreies Getränk | 0,70 | |||
| 7, gesund | 500 | 28 | Kapsel mit Piperin | 2967,25 |
| 40, gesund, wiederholte sequenzielle Dosierung | 500 | 29 | Caplet | 43,8 |
| 1000 | 141 | |||
| 2500 | 331 | |||
| 5000 | 967 | |||
| 6, Patienten mit hepatischen Metastasen, randomisierte doppelblinde klinische Studie | 5000 | 14 | Mikronisiertes Resveratrol gemischt in Flüssigkeit | 1942 |
| 8, gesunde Probanden | 2000 | 7 | Kapsel | 1274 |
| 19, übergewichtig oder adipös, randomisierte, doppelblinde, placebokontrollierte, crossover Interventionsstudie | 30 | 6 | Kapsel | 181,31 |
| 90 | 532,00 | |||
| 270 | 1232,16 |
- ↑ Springer M & Moco S: Resveratrol and Its Human Metabolites-Effects on Metabolic Health and Obesity. Nutrients 2019. (PMID 30641865) [PubMed] [DOI] [Full text] Resveratrol is one of the most widely studied polyphenols and it has been assigned a plethora of metabolic effects with potential health benefits. Given its low bioavailability and extensive metabolism, clinical studies using resveratrol have not always replicated in vitro observations. In this review, we discuss human metabolism and biotransformation of resveratrol, and reported molecular mechanisms of action, within the context of metabolic health and obesity. Resveratrol has been described as mimicking caloric restriction, leading to improved exercise performance and insulin sensitivity (increasing energy expenditure), as well as having a body fat-lowering effect by inhibiting adipogenesis, and increasing lipid mobilization in adipose tissue. These multi-organ effects place resveratrol as an anti-obesity bioactive of potential therapeutic use.