Sprague Dawley rats

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    The Sprague Dawley is an outbred, multipurpose breed of albino rat used extensively in medical and nutritional research.[1][2][3][4] Its main advantage is its calmness and ease of handling.[5] This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague Dawley Animal Company) in Madison, Wisconsin, in 1925. The name was originally hyphenated, although the brand styling today (Sprague Dawley, the trademark used by Envigo) is not. The average litter size of the Sprague Dawley rat is 11.0.[6]

    These rats typically have a longer tail in proportion to their body length than Wistars. They were involved in the Séralini affair, where the herbicide RoundUp was claimed to increase the occurrence of tumor in these rats. However, since these rats are known to grow tumors at a high (and very variable) rate, the study was considered flawed in design and its findings unsubstantiated.

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    References[edit | edit source]

    1. Drachman RH, Root RK, Wood WB; "Studies on the effect of experimental nonketotic diabetes mellitus on antibacterial defense. I. Demonstration of a defect in phagocytosis" , https://doi.org/10.1084/jem.124.2.227
    2. Hsu CC, Lai SC; "Matrix metalloproteinase-2, -9 and -13 are involved in fibronectin degradation of rat lung granulomatous fibrosis caused by Angiostrongylus cantonensis'" , https://doi.org/10.1111/j.1365-2613.2007.00554.x
    3. Horiuchi N, Suda T, Sasaki S, Takahashi H, Shimazawa E, Ogata E; "Absence of regulatory effects of 1alpha25-dihydroxyvitamin D3 on 25-hydroxyvitamin D metabolism in rats constantly infused with parathyroid hormone" , https://doi.org/10.1016/0006-291X(76)90202-3
    4. Sukov W, Barth DS; "Three-dimensional analysis of spontaneous and thalamically evoked gamma oscillations in auditory cortex" , https://doi.org/10.1152/jn.1998.79.6.2875
    5. Online Medical Dictionary, http://cancerweb.ncl.ac.uk/cgi-bin/omd?rats,+sprague-dawley
    6. Sprague Dawley Outbred Rat, http://www.harlan.com/products_and_services/research_models_and_services/research_models/sprague_dawley_outbred_rat.hl