2,869
edits
SIRT1: Difference between revisions
→See also
No edit summary |
|||
| (2 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
[[File:SIRTUIN1.png|right|frameless]] | |||
'''SIRT1''' is one of the seven mammalian [[Sirtuins|sirtuins]], a family of proteins critical to cellular regulation and longevity. Sirtuins, in general, are known for their role in extending lifespan and improving health. SIRT1 is particularly noteworthy due to its extensive involvement in cellular processes that are directly linked to the aging process, including cellular metabolism, inflammation, stress resistance, and survival. | '''SIRT1''' is one of the seven mammalian [[Sirtuins|sirtuins]], a family of proteins critical to cellular regulation and longevity. Sirtuins, in general, are known for their role in extending lifespan and improving health. SIRT1 is particularly noteworthy due to its extensive involvement in cellular processes that are directly linked to the aging process, including cellular metabolism, inflammation, stress resistance, and survival. | ||
| Line 23: | Line 24: | ||
==== SIRT1 Activating Compounds (STACs) ==== | ==== SIRT1 Activating Compounds (STACs) ==== | ||
Resveratrol is one of the most well-known and studied SIRT1 Activating Compounds (STACs). It is a natural polyphenolic compound found in grapes, berries, peanuts, and red wine. | [[Resveratrol]] is one of the most well-known and studied SIRT1 Activating Compounds (STACs). It is a natural polyphenolic compound found in grapes, berries, peanuts, and red wine. Resveratrol mimics the effects of caloric restriction by modulating the same pathways and has shown to confer protective effects against various diseases, including cardiovascular and neurodegenerative diseases. | ||
In addition to resveratrol, several other synthetic and natural STACs have been identified, such as SRT1720, SRT2104, and [[Quercetin|quercetin]]. These compounds have demonstrated the potential to enhance SIRT1 activity, modulate metabolic processes, and extend lifespan in various animal models. The translational potential of these compounds, including resveratrol, to human health and longevity remains to be fully elucidated, with ongoing studies aimed at understanding their efficacy, optimal dosages, and mechanisms of action. | In addition to resveratrol, several other synthetic and natural STACs have been identified, such as SRT1720, SRT2104, and [[Quercetin|quercetin]]. These compounds have demonstrated the potential to enhance SIRT1 activity, modulate metabolic processes, and extend lifespan in various animal models. The translational potential of these compounds, including resveratrol, to human health and longevity remains to be fully elucidated, with ongoing studies aimed at understanding their efficacy, optimal dosages, and mechanisms of action. | ||
| Line 41: | Line 42: | ||
== See also == | == See also == | ||
* [[ | * [[Sirtuins]] | ||
* {{SeeWikipedia|SIRT1}} | |||
[[Category:Molecular and Cellular Biology]] | [[Category:Molecular and Cellular Biology]] | ||