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Telomere Attrition: Difference between revisions
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'''Telomere Attrition''' is a biological process that refers to the progressive shortening of telomeres, which are the protective end caps of chromosomes. Every time a cell divides, telomeres shorten slightly due to the inability of DNA polymerases to completely replicate the end of linear chromosomes. This gradual shortening can eventually lead to the loss of vital genetic information and signal cells to stop dividing or enter into a state of senescence or apoptosis. Telomere attrition is considered one of the primary hallmarks of aging and has been associated with various age-related diseases and conditions. | '''Telomere Attrition''' is a biological process that refers to the progressive shortening of telomeres, which are the protective end caps of chromosomes. Every time a cell divides, telomeres shorten slightly due to the inability of DNA polymerases to completely replicate the end of linear chromosomes. This gradual shortening can eventually lead to the loss of vital genetic information and signal cells to stop dividing or enter into a state of senescence or apoptosis. Telomere attrition is considered one of the primary hallmarks of aging and has been associated with various age-related diseases and conditions. | ||
==Telomeres and Their Function== | ==Telomeres and Their Function== | ||
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*'''Telomerase Activation''': Strategies to safely activate telomerase in somatic cells are being explored to extend the replicative capacity of cells and possibly delay aging. | *'''Telomerase Activation''': Strategies to safely activate telomerase in somatic cells are being explored to extend the replicative capacity of cells and possibly delay aging. | ||
*'''Lifestyle Factors''': Studies have shown that lifestyle factors such as diet, exercise, and stress reduction can impact telomere length and the rate of telomere attrition. | *'''Lifestyle Factors''': Studies have shown that lifestyle factors such as diet, exercise, and stress reduction can impact telomere length and the rate of telomere attrition. | ||
*'''Antioxidants and Anti-inflammatory Agents''': Since oxidative stress and inflammation can accelerate telomere shortening, these agents are being studied for their potential to slow down the rate of telomere attrition. | *'''[[Antioxidant|Antioxidants]] and Anti-inflammatory Agents''': Since [[Oxidative Stress|oxidative stress]] and inflammation can accelerate telomere shortening, these agents are being studied for their potential to slow down the rate of telomere attrition. | ||
== See Also == | == See Also == | ||