2,869
edits
Spermidine: Difference between revisions
→Autophagy
| (9 intermediate revisions by the same user not shown) | |||
| Line 63: | Line 63: | ||
==Spermidine and Longevity== | ==Spermidine and Longevity== | ||
Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice. The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy{{#pmid:27841876|pmid27841876}}. | Research has identified a significant correlation between the exogenous supplementation of spermidine and increased lifespan in several model organisms such as yeast, worms, flies, and mice.<ref>https://genomics.senescence.info/drugs/browse.php?search_term=spermidine</ref> The longevity-promoting properties of spermidine are primarily attributed to its role in inducing autophagy.{{#pmid:27841876|pmid27841876}} | ||
The [[Interventions Testing Program (ITP)]] gave mice spermidine for 6 month. However, no increase in spermidine or spermine levels was observed in the blood, liver, or other tissues. The lack of change in spermidine levels led to the decision not to proceed with further lifespan testing in mice.<ref>[[2022-04-12 - Dr. Richard Miller - Longevity Supplements - Interventions Testing Program Results]]</ref> | |||
=== Autophagy === | === Autophagy === | ||
Autophagy is a cellular process involved in the degradation and recycling of obsolete or dysfunctional cellular components. This mechanism is vital for maintaining cellular homeostasis and plays a central role in cell and tissue health. Spermidine's ability to enhance autophagy is of particular interest in the context of aging, as the decline in autophagy has been associated with several age-related pathologies, including neurodegeneration, cardiovascular disease, and cancer. | [[Autophagy]] is a cellular process involved in the degradation and recycling of obsolete or dysfunctional cellular components. This mechanism is vital for maintaining cellular homeostasis and plays a central role in cell and tissue health. Spermidine's ability to enhance autophagy is of particular interest in the context of aging, as the decline in autophagy has been associated with several age-related pathologies, including neurodegeneration, cardiovascular disease, and cancer. | ||
Spermidine promotes autophagy through the inhibition of a specific enzyme called acetyltransferase EP300. This inhibition leads to a series of cellular events that eventually increase the autophagic processes within the cells. Essentially, spermidine helps in "cleaning up" the cell interiors, which is crucial for cellular maintenance and health, especially as the body ages{{#pmid:25526088|pmid25526088}}. | Spermidine promotes autophagy through the inhibition of a specific enzyme called acetyltransferase EP300. This inhibition leads to a series of cellular events that eventually increase the autophagic processes within the cells. Essentially, spermidine helps in "cleaning up" the cell interiors, which is crucial for cellular maintenance and health, especially as the body ages{{#pmid:25526088|pmid25526088}}. | ||
=== Cardiovascular Health === | === Cardiovascular Health === | ||
Apart from its role in autophagy, spermidine has been observed to contribute to cardiovascular health. A study demonstrated that oral supplementation of spermidine (as well as spermine) extended the lifespan of mice and exerted cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Moreover, spermidine feeding enhanced cardiac autophagy, mitophagy, and mitochondrial respiration, also improving the mechano-elastical properties of cardiomyocytes in vivo. In a model of hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. High levels of dietary spermidine in humans, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease | Apart from its role in autophagy, spermidine has been observed to contribute to cardiovascular health. A study demonstrated that oral supplementation of spermidine (as well as spermine) extended the lifespan of mice and exerted cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice. Moreover, spermidine feeding enhanced cardiac autophagy, mitophagy, and mitochondrial respiration, also improving the mechano-elastical properties of cardiomyocytes in vivo. In a model of hypertension-induced congestive heart failure, spermidine feeding reduced systemic blood pressure, prevented cardiac hypertrophy and a decline in diastolic function, thus delaying the progression to heart failure. High levels of dietary spermidine in humans, as assessed from food questionnaires, correlated with reduced blood pressure and a lower incidence of cardiovascular disease{{#pmid:27841876|pmid27841876}}. | ||
== Bioavailability == | == Bioavailability == | ||
| Line 92: | Line 94: | ||
== See Also == | == See Also == | ||
* | * {{SeeWikipedia|Spermidine|}} | ||
== ToDo== | |||
* https://phys.org/news/2024-01-deciphering-molecular-mysteries-insights-metabolites.html | |||
==References== | ==References== | ||
<references /> | <references /> | ||
[[Category:Orally Consumable Longevity | [[Category:Orally Consumable Longevity Compounds]] | ||