Model Organisms

    From Longevity Wiki

    Model organisms are non-human species that are extensively studied to understand particular biological phenomena, with the expectation that discoveries made in the organism model will provide insight into the workings of other organisms. In longevity research, model organisms are crucial for understanding the mechanisms of aging and developing interventions to extend lifespan and improve healthspan.

    Importance in Longevity Research[edit | edit source]

    Model organisms offer several advantages in longevity research:

    • Genetic Manipulation: Easy to genetically manipulate, allowing researchers to study the effects of specific genes on aging.
    • Short Lifespan: Many have short lifespans, enabling the study of genetic and environmental impacts on aging within a reasonable timeframe.
    • Conserved Pathways: They often share many biological pathways with humans, making it possible to translate findings into human aging research.

    Common Model Organisms[edit | edit source]

    Organism Lifespan Use in Research
    Yeast (Saccharomyces Cerevisiae) Days Studying cellular aging, replication, and metabolism
    Nematode Worms (Caenorhabditis Elegans) 2-3 weeks Genetic and pharmacological studies in aging
    Fruit Flies (Drosophila Melanogaster) 40-50 days Genetic regulation of aging and age-related diseases
    Mice (Mus Musculus) 1-2 years Aging and age-associated diseases research, genetic similarity to humans
    Rats (Rattus Norvegicus) 2-3 years Used in a variety of aging studies, including age-related diseases and neurobiology
    Zebrafishes (Danio Rerio) 3-5 years Vertebrate development and genetics, including aging processes
    Rhesus Monkeys (Macaca Mulatta) Up to 40 years Studies relevant for human aging due to close genetic relation

    See Also[edit | edit source]

    References[edit | edit source]