The Area Under the Curve (AUC) is a critical parameter in pharmacokinetics, representing the integral of the drug concentration-time curve. It quantifies the total drug exposure over time, providing vital information on drug absorption, distribution, metabolism, and elimination.
Definition[edit | edit source]
- is the drug concentration at time
AUC offers insight into the extent and rate of drug absorption, making it a fundamental measure to assess bioavailability and bioequivalence of drugs.
Types of AUC[edit | edit source]
Several types of AUC values exist, each serving unique purposes in pharmacokinetic studies:
|Area under the concentration-time curve up to the last measurable concentration.
|Used to determine the total exposure of the body to the drug until the last measurable concentration.
|Represents the total area under the concentration-time curve from administration to infinity.
|Provides an estimate of the total exposure of the body to a drug. Useful for evaluating the overall efficacy of a drug.
|Area under the concentration-time curve from the administration up to a specific time 't'.
|Useful for focusing on drug exposure within specific time windows.
|Area under the concentration-time curve from administration up to 24 hours.
|Often used when drugs are administered once a day.
|Area under the concentration-time curve over a dosing interval 'tau', for example in repeated dosing every 12 or 24 hours.
|Helpful in evaluating steady-state pharmacokinetics in multiple dosing regimens.
|Utilizes microdosing studies and mass spectrometric analyses to determine the AUC for drugs administered in very low concentrations.
|Suitable for studying the pharmacokinetics of drugs at subtherapeutic, micro-level doses.
Application[edit | edit source]
AUC is indispensable in pharmacology and drug development:
- It is pivotal for determining the dosage and frequency of drug administration.
- It aids in evaluating the bioequivalence of generic drugs to brand-name counterparts.
- It enables researchers to study the pharmacokinetics of new drug candidates.